Setton returned to Gossip Girl in 2010. It was announced on June 22, 2011 that Setton would be returning to One Life to Live as Kimberly Andrews in August 2011. On July 11, 2012, Setton was cast as a series regular on the Fox comedy series The Mindy Project, playing the role of Shauna Dicanio. However, it was reported on November 20, 2012 that her character would be written out of the show. Setton had a guest role on the pilot episode of the CBS crime drama series Golden Boy, which premiered February 26, 2013, the same day that Setton was cast in the CBS sitcom The Crazy Ones. She played recurring character Dr. Mindy Shaw during the fifth season of Hawaii Five-0.