Sciorra was married to actor Joe Petruzzi from 1989 to 1993. In 2004, she began a relationship with Bobby Cannavale which lasted for three years; the pair split in 2007.
Sciorra continued to work steadily throughout the 1990s. Film parts included The Night We Never Met, with Matthew Broderick (1993); Romeo is Bleeding, with Gary Oldman (1993); Mr. Wonderful, with Matt Dillon (1993); The Addiction, with Christopher Walken (1994); Cop Land, with Sylvester Stallone (1997); and What Dreams May Come (1998), in which she co-starred for a second time with Robin Williams.
She earned widespread attention in 1991 for her co-lead role in Spike Lee's film, Jungle Fever, opposite Wesley Snipes. In his review for The Los Angeles Times, Kenneth Turan wrote that Sciorra was "possessed of considerable presence, assurance and vulnerability". She then starred alongside Rebecca DeMornay in Curtis Hanson's 1992 thriller, The Hand That Rocks The Cradle, which held the #1 position at the North American box office for four consecutive weeks.
In 2001, she received a nomination for the Primetime Emmy Award for Outstanding Guest Actress in a Drama Series for her portrayal of Gloria Trillo on the HBO series The Sopranos. Entertainment Weekly called it "a career changing performance".
Subsequent credits include the CBS series Queens Supreme (2003); a recurring role as Det. Carolyn Barek on Law & Order: Criminal Intent (2005–06); the FOX series Mental (2009); and guest appearances on The L Word, ER, The Good Wife, and CSI: Crime Scene Investigation. In 2018, she appeared in Luke Cage season 2 as Rosalie Carbone.
In 2006, Sciorra co-starred with Vin Diesel in Find Me Guilty, directed by Sidney Lumet. The film, based on the true story of the longest Mafia trial in American history, was described as "gripping" by Stephen Holden of The New York Times, who also called Sciorra's performance "excellent".
In October 2017, Sciorra brought allegations of sexual assault against the film Producer Harvey Weinstein. In an article published by The New Yorker, Sciorra alleged Weinstein raped her after he forced his way into her apartment in the 1990s.
