Austen Chamberlain was born in Birmingham, the second child and eldest son of Joseph Chamberlain, then a rising industrialist and political radical, later Mayor of Birmingham and a dominant figure in Liberal and Unionist politics at the end of the 19th century. His mother, the former Harriet Kenrick, died in childbirth, leaving his father so shaken that for almost 25 years he maintained a distance from his first-born son. In 1868, his father married Harriet's cousin, Florence, and had further children, the oldest of whom, Arthur Neville, would become Prime Minister in the year of Austen's death.