Mamabolo has released her first record with her band Mamabolo entitled "Falling to Pieces". The band has toured with Men Without Hats and has performed at the NXNE and Montreal Jazz Festivals. Barbara Mamabolo performed one of the band's singles, "Night After Night", in the 2009 film Suck.
She also voices a character in the reboot of the Spyro the Dragon franchise. She voices Cynder in the original Skylanders: Spyro's Adventure (2011).
Mamabolo has made guest-star appearances on the critically acclaimed series The Eleventh Hour, Sue Thomas: F.B. Eye, and Relic Hunter. Her stage credits include the role of Becky at the Tarragon Theatre’s production of The Little Princess, a principal role in Ross Petty’s Peter Pan at the Elgin Theatre, Dorothy in the Leah Polsun Theatre's production of The Wizard of Oz, and a member of the ensemble cast of Judy and David in Concert at the Ford Centre. She also played the role of Jude Harrison's best friend, Katarina "Kat" Benton, in first season of the hit Canadian teen drama television series, Instant Star. Mamabolo also appeared, albeit briefly, in two episodes of the Canadian drama, MVP (TV series). Mamabolo's most recent movie appearance as of 2006 was in 5ive Girls. She played the role of Robin in Confessions of a Teenage Drama Queen, alongside the antagonist (Megan Fox).
