In 2001 at the request of the current President and CEO, Paul Wakfer, Best became President and CEO of The Institute For Neural Cryobiology (INC). Ben thus helped to ensure the completion of the Hippocampal Slice Cryopreservation Project (HSCP), which had begun in 1998, as a direct result of The Prometheus Project begun by Wakfer in 1996. HSCP, which was being funded jointly by INC. and Harbor-UCLA Research and Education Institute. was a project focused on vitrification of rat brain hippocampal slices which involved cooling to −130 degrees Celsius, rewarming and testing for viability. Discoveries from this research have been incorporated into the vitrification formulations of Twenty-First Century Medicine. Dr. Yuri Pichugin was brought to the US from the Ukraine by Wakfer and Dr. Robert J. Morin, Research Professor of Pathology at REI and Chairman of the Department of Pathology at Harbor-UCLA, to conduct the research for this project at Harbor-UCLA under the direction of Morin as Principal Investigator and Dr. Gregory M. Fahy, Chief Scientific Officer of Twenty-First Century Medicine, as Consulting Investigator. The results of the HSPC were published in the April 2006 issue of the journal Cryobiology.