Myerson stepped down from her other commitments in 1969 when appointed by Mayor John V. Lindsay to become the first Commissioner of the New York City Department of Consumer Affairs. Her career as a commercial pitchwoman for a number of products throughout the 1950s and 1960s had led to her becoming a consultant to several consumer products companies. In her consumer affairs position, which she held until 1973, she became a pioneer in consumer protection law. She also served on several presidential commissions on violence, mental health, workplace issues, and hunger in the 1960s and 1970s. Throughout the late 1970s and the beginning of his mayoral ambitions, Myerson was a frequent public companion of then-Congressman Ed Koch and later chaired his successful 1977 campaign for New York City mayor.