Von Zerneck began her acting career in commercials and Television films. From 1983-1984, she played Louisa "Lou" Swenson on General Hospital. In She is perhaps best known for her portrayal of Donna, Ritchie Valens' girlfriend in the film La Bamba (1987). Her last acting credit was in the 2001 television film Acceptable Risk, based on the novel of the same name. She has worked primarily as a film Producer in recent years.