Sarafian has directed 23 episodes of the FOX series House and was made a co-executive Producer of the series from 2007 and 2009; during this time he won two People's Choice Award's, and earned himself the AFI Award for Best Director in 2007. He was the producing Director for several episodes of the first season of CSI: NY. Sarafian has also directed installments of: CSI: Crime Scene Investigation, CSI: Miami, Cold Case, The District, Without a Trace, Buffy the Vampire Slayer, Nash Bridges, Fringe, The Cape, Lost (TV series), Hell on Wheels (TV Series) and Nikita.