Before the Romans took control of present-day Emilia-Romagna, it had been part of the Etruscan world and then that of the Gauls. During the first thousand years of Christianity trade flourished, as did culture and religion, thanks to the region's monasteries. Afterwards the University of Bologna—arguably the oldest university in Europe—and its bustling towns kept trade and intellectual life alive. Its unstable political history is exemplified in such figures as Matilda of Canossa and struggling seigniories such as the Este of Ferrara, the Malatesta of Rimini, the Popes of Rome, the Farnese of Parma and Piacenza, and the Duchy of Modena and Reggio. In the 16th century, most of these were seized by the Papal States, but the territories of Parma, Piacenza, and Modena remained independent until Emilia-Romagna became part of the Italian kingdom between 1859 and 1861.