In 2002, the St. Louis Film Festival awarded Daniels the Emerging Star Award. She appeared in One Hour Photo, Wheelmen, and House of 1000 Corpses before becoming a major cast member of Showtime's The L Word. Her depiction of Dana Fairbanks on that show prompted an anonymous donation of a million dollars to the Dr. Susan Love Research Foundation, an organization that promotes and funds breast cancer intraductal research.