Wyner was born in Boston, Massachusetts. His father, Edward, founded and managed Boston's Ritz Carlton Hotel, which was the premier society hotel in Boston through the 1950s. Wyner's father died while his son was in high school. Wyner's family is Jewish.
Wyner was introduced to Producer Steven Bochco while appearing in Bochco's short-lived 1976 series, Delvecchio. This led to the role as Irwin Bernstein in Hill Street, and to roles in 4 subsequent Bochco productions: Doogie Howser, M.D., Brooklyn South, NYPD Blue and L.A. Law. Additionally, Wyner has appeared on the following programs for Hill Street's production company, MTM: Rhoda, The Bob Newhart Show, The White Shadow, WKRP in Cincinnati and Newhart.
