Mistry first gained exposure playing Dr Fred Fonseca on BBC TV's EastEnders, and has since worked on film and stage. His work includes starring roles in East Is East, The Guru with Heather Graham and Marisa Tomei, Blood Diamond opposite Leonardo DiCaprio, Guy Ritchie's RocknRolla and Partition with Kristin Kreuk. He can be seen in the film 2012 from Director Roland Emmerich opposite John Cusack, Danny Glover, Amanda Peet and Thandie Newton, and the BAFTA-nominated movie Exam.