"I played a manic depressive Glaswegian in the play and I'd seen Jim (Sweeney) on the circuit when I was a singer with Denise Black and The Kray Sisters. So I stayed behind and watched one night and then, because I knew Jim, I said could I try it because it looked brilliant and it was one of those things I found I could do. You suddenly find your little baby. After that I joined The Comedy Store Players and then this TV show called Whose Line Is It Anyway? came along."
She studied at Dartington College of Arts from 1978 to 1981, receiving a Bachelor of Arts honours degree.
Her first acting role was as a young boy in a production of The Ragged Trousered Philanthropists at the Half Moon Theatre. During the 1980s, she was also involved in a play called Passionaria at the Newcastle Playhouse, starring Denise Black and Kate McKenzie, and they later formed the jazz group Denise Black and the Kray Sisters.
Lawrence came to public attention as a regular guest on the Channel 4 improvisational comedy series Whose Line Is It Anyway? at its launch in 1988. Lawrence's speciality on Whose Line was her ability to improvise songs on the spot. She was the first female performer to regularly perform and featured on the show until 1997, which was the final UK series to be made in London. She also performed in two episodes of the American edition of the show in 1999.
She appeared on the 1992/1993 series of GamesMaster, playing Mad Dog McCree winning her challenge.
Lawrence starred in three series of the improvised comedy series The Masterson Inheritance from 1993 to 1995 on BBC Radio 4 alongside Paul Merton, Phelim McDermott, Caroline Quentin, Lee Simpson and Jim Sweeney. Each episode comprised a different time period, and the plots were improvised based on suggestions from the studio audience. One unaired episode was produced and narrated by Lawrence, but it was released on the internet by Jim Sweeney on his official site.
In 1994–1996 Lawrence played Katharine in the Royal Shakespeare Company production of The Taming of the Shrew in both Stratford-upon-Avon and London, for which she received a Dame Peggy Ashcroft award for Best Actress. She also appeared in Faust and The Cherry Orchard and starred as Benedick in an all-female production of Much Ado About Nothing at Shakespeare's Globe, having played Beatrice previously at Manchester's Royal Exchange. She made her West End theatre debut in 2001 taking over the lead role of Anna in the stage musical The King and I, replacing Elaine Paige. In 2005, she appeared with Victoria Wood, Julie Walters and Celia Imrie in the cult West End production of Wood's Acorn Antiques: The Musical.
In 1996, Josie Lawrence was awarded an honorary doctorate by Dartington College of Arts, and she has since been awarded a further two, an honorary doctorate of letters from the University of Wolverhampton in 2004 and in 2006 a doctorate by Aston University for "services to the entertainment industry."
She has starred in three other BBC Radio 4 comedy series: the science fiction comedy Married in 1996 and the dark comedy series Vent in 2006 as well as appearing in a Galton and Simpson Radio Playhouse 50th Anniversary recording of Clicquot et Fils alongside Richard Griffiths and Roger Lloyd-Pack that originally aired on 29 December 1998.
In 2003 Lawrence spent eight months walking across China, Cuba, Peru and Tanzania for Breakthrough Breast Cancer and helped to raise over £550,000. She had to wear a knee brace throughout the trek because of damage to her anterior cruciate ligament.
In 2006 she starred alongside Peter Davison in The Complete Guide to Parenting as Phoebe Huntley. She has also appeared in the BBC 1 drama series Robin Hood and as Mrs Jiniwin in the 2007 ITV adaptation of The Old Curiosity Shop. She appeared in an episode of the 2007 E4 teen comedy/drama Skins, playing Liz Jenkins, estranged mother of Sid Jenkins, a role which she reprised in the second series.
The BBC Radio 4 series The Lawrence Sweeney Mix aired from 27 February to 20 March 2007 and was described as "Josie Lawrence and Jim Sweeney create improvised sketches from audience suggestions". Series 2 began airing on 29 January 2008.
In 2005 she climbed Mount Kilimanjaro for Sunfield, a school for children with autism and complex learning needs, of which she is a patron. On 21 April 2008, she hosted a VIP-night performance of Hapgood at The Birmingham Rep in aid of Sunfield and raised a further £3,500 for the charity. She is also a supporter of the National Autistic Society's Make School Make Sense campaign. In 2009, Lawrence raised £25,000 for Sunfield by appearing on Who Wants to Be a Millionaire? with Meera Syal.
Lawrence and actor Shane Richie participated in the final leg of the Celebrity Around the World in 80 Days challenge to raise money for Children in Need 2009. They travelled from Memphis to Wilmington, North Carolina and then to London over 15 days.
In 2010 Lawrence appeared in series 25, episode 3 of Casualty named "The Chaos Theory". Lawrence played Mrs Janet Haines, head Teacher of a school where sixteen children were admitted to the emergency department having taken LSD. Also in 2010 she played the part of Sandra, Tony's agent, in the 2010 British feature film version of Tony Hawks' best selling book Round Ireland with a Fridge that was released in September 2010 and was released on DVD in November 2010.
In 2012, she appeared in Doctors alongside Louise Jameson who has also appeared in EastEnders. Lawrence played Cathy Dayman, and Jameson played Shirley Carter. Also in 2012, she appeared on one episode of the US improv series, Trust Us With Your Life, similar to Whose Line is it Anyway?, but never made it to air.
In December 2014, Lawrence played the role of Agnes Nutter in an adaptation of Terry Pratchett and Neil Gaiman's book Good Omens for BBC Radio 4.
Lawrence provided the voice of "The Brain" in the 2015 BBC Two quiz show Beat The Brain.
