Brothers gained fame in late 1955 by winning The $64,000 Question game show, on which she appeared as an expert in the subject area of boxing. Originally, she had not planned to have boxing as her topic, but the sponsors suggested it, and she agreed. A voracious reader, she studied every reference book about boxing that she could find; she would later tell reporters that it was thanks to her good memory that she assimilated so much material and answered even the most difficult questions. After seven weeks on the show she became the second person, and only woman, to win the $64,000 top prize. Two years later, Brothers appeared on a successor program, The $64,000 Challenge, which matched the contestant against experts in the field. Again, Brothers walked off with the maximum prize.