Jameson began work in the early 1950s with numerous uncredited roles in films and television. She made her film debut in 1951 playing a chorus girl Dancer in the motion picture Show Boat. Other notable film credits of that early period included Problem Girls (1953), Tip on a Dead Jockey (1957) and The Apartment (1960).
Jameson's Broadway credits include Venus at Large (1961), The Billy Barnes People (1961) and The Billy Barnes Revue (1959).
In 1962, she starred with Vincent Price and Peter Lorre in the Roger Corman horror film Tales of Terror as Annabel Herringbone. She played Lorre's vulgar, unfaithful wife, and during the course of the film, she and her paramour (Price) were locked up in Lorre's wine cellar. One year later, she again starred with Lorre and Price in the raucous comedy The Comedy of Terrors (released in 1964). In 1964, she appeared as a hotel hooker in the comedy Good Neighbor Sam, starring Jack Lemmon and Romy Schneider.
Jameson was also a television Actress. She was a regular member of the cast on Club Oasis. She made two appearances on Perry Mason: first as Lorraine Iverson who killed her husband in the 1963 episode "The Case of the Floating Stones", then as Dolly Jameson in the 1965 episode, "The Case of the Feather Cloak". She also had roles on The Dick Van Dyke Show, Gunsmoke, Stagecoach West, The Twilight Zone, McHale's Navy, My Favorite Martian, The Munsters, F-Troop, Hogan's Heroes (in the 1967 episode "The Great Brinksmeyer Robbery" as Mady Pleiffer), Alias Smith and Jones, Emergency! and Barney Miller. She appeared in The Rockford Files (in the 1974 episode "The Dexter Crisis" as Marge White). Later she appeared in Charlie's Angels, The Feather and Father Gang, and The Love Boat.
She was married to actor/songwriter Billy Barnes for many years; they had one child, a son named Tyler Barnes. Subsequently, Jameson was a longtime girlfriend of The Man from U.N.C.L.E. star Robert Vaughn. She acted opposite Vaughn as the guest star on a 1966 U.N.C.L.E. episode "The Dippy Blond Affair".
On January 16, 1987, Jameson committed suicide by overdosing on pills at the age of 54. Her body was cremated and her ashes scattered at sea.
Jameson had roles in Death Race 2000 (1975) playing Grace Pander, The Outlaw Josey Wales (1076) as Rose, Every Which Way but Loose (1978), and Hardbodies (1984).
