From February 3, 2005 through November 2005, Wuhrer joined the cast of the daytime soap opera General Hospital as FBI Agent Reese Marshall, the former love interest of mobster Sonny Corinthos and former best friend/rival of Carly Corinthos. Wuhrer's character died after suffering injuries in a train wreck. In January 2006, Wuhrer announced that she was suing General Hospital, claiming that she was fired because of her pregnancy. The case was resolved in December 2006.