Ross was discovered by Mario Testino on Portobello Road in London, where he asked her and a group of friends to do a shoot for British Vogue. She worked sporadically as a model throughout her childhood. She appeared on Ozzy Osbourne's No Rest for the Wicked album cover at the age of nine. In 1992 she signed with Storm Model Management.
In 2000, Ross became the face of an Emanuel Ungaro ad campaign. In May, Ross appeared on the twentieth anniversary cover of The Face alongside Kate Moss. In June, Ross appeared on the cover of British Vogue, shot by personal friend Mario Testino. Ross was then awarded Model of the Year at the Elle Style Awards.
Ross was photographed by Robin Derrick for the December 2000/January 2001 issue of Vogue Russia. In 2002, Ross shot Burberry's spring campaign alongside Kate Moss and Eva Herzigova. In January 2002, Ross was again featured on the cover of British Vogue, also photographed by Testino, alongside nine other British Models including Kate Moss, Naomi Campbell, Stella Tennant and Erin O'Connor. Ross also appeared on the November 2002 cover of British magazine i-D, photographed by Kayt Jones.
In 2003, Ross became the face of the luxury footwear brand Jimmy Choo. She also modelled for the cover of Vogue Russia, photographed by Todd Barry.
In 2004 she modelled for Dior's Addict perfume. Ross then appeared in the Pirelli Calendar, photographed by Nick Knight. Shortly after, Ross began a three-year hiatus to focus on her family life that ended in 2007 when she re-signed with Storm.
Ross also contributed to British Vogue's online blog from 2009 to 2012.
Following her husband's well publicised affair, Ross began to stage a career comeback, appearing on the cover of online magazine The Edit and in the pages of Vanity Fair. Ross made her runway return in September 2012, walking for Alexander Wang at New York Fashion Week.
In 2014 Ross confirmed she was dating record Producer Jimmy Iovine. They married in front of their Malibu beach house on Valentine's Day, 2016, with friends and family in attendance.
