Esco has been showcased in various commercial, music videos, magazines and publications. In 2001, she was featured in the Sinéad O'Connor music video "Jealous". She appears briefly in Moby's music video for "Southside" featuring Gwen Stefani. She was also an extra for a series of Axe commercials one including with Nick Lachey for the “Clix” campaign in 2007. Esco also features in Halos's music video for "Amalgam" in 2010.
Esco's film debut was in 2005 with London. She is a supporting character in the 2012 comedy LOL.
Esco was cast in her first television guest star role in 2006, as Angie Watson in series CSI: NY. In March, 2007 Esco joined the cast of the CBS drama Cane. In 2009, she guest starred in an episode of Drop Dead Diva series with Paula Abdul. Esco played a lingerie model who had been fired for going public about her breast cancer survival story.
Esco has been very involved in two organizations. Dolphin Project, which has gained much support from many celebrities, is an organization led by Richard O'Barry and aims to prevent dolphin slaughter and exploitation from occurring. On September 9, 2009, Esco held a private screening of The Cove in New York, alongside Russell Simmons and Fisher Stevens hosting the event to bring awareness on the film.
In April 2010, Esco produced "My Friend is...", a public Service announcement for the Academy Award-winning documentary The Cove alongside Oscar-winning Producer Fisher Stevens joined forces with celebrities: Jennifer Aniston, Ben Stiller, Robin Williams, Hayden Panettiere, Paul Rudd, Naomi Watts, Courteney Cox, Mariska Hargitay, Richard O'Barry, Woody Harrelson, Jason Mraz, James Gandolfini, John Leguizamo, Evan Handler, Rob Morrow, Tamlyn Tomita, Carrie Ann Inaba, Chris Tashima, Russell Simmons, James Kyson Lee and Richard Kind to bring awareness on the annual killing of dolphins in Taiji, Japan.
On May 16, 2011 Esco was featured in Ketel One ad campaign "Gentlemen, This is Vodka." directed by Academy Award Nominee, David O. Russell.
She directed "Kids Speak Out Against Dolphin Captivity", a 2012 public Service announcement for The Cove . She directed Free the Nipple in a bid to circumvent female nipple censorship.
Esco is in a 2013 NFL Women's Apparel Collection TV advertisement.
She directed and starred in Free the Nipple, which was released in select theaters, video on demand and on iTunes on December 12, 2014.
In 2017, Esco was featured on the Audience network's Midnight Snack on Fullscreen (What's Underneath), where the guests remove their clothing on camera while talking about their life.
