Marcos Galperín was born in Buenos Aires, Argentina, to a wealthy family, owners of SADESA, one of the largest leather companies in the world. He attended Colegio San Andrés in Olivos. In 1990, after graduating from high school, he traveled to the United States to study Finance at The Wharton School of the University of Pennsylvania. There, he became friends with José Estenssoro, YPF president's son. In 1994, he joined this company when he finished college and returned to Argentina.