She appeared in two films directed by Stanley Kubrick: 2001: A Space Odyssey (1968) and A Clockwork Orange (1971). Tyzack also appeared in Ring of Spies (1964), The Whisperers (1967), A Touch of Love (1969), The Legacy (1978), The Quatermass Conclusion (1979), Mr. Love (1985), Prick Up Your Ears (1987), The King's Whore (1990), Mrs Dalloway (1997), Bright Young Things (2003), and the Woody Allen films Match Point (2005) and Scoop (2006).