After starting his career acting in commercials, Ghanimé was cast in his first guest-starring role as Graham in the CBC Television series Wild Roses. He then had small guest starring roles on Smallville and Supernatural in 2010 and The Secret Circle, Fairly Legal, and Arrow in 2012. Starting in 2012, Ghanimé had a recurring role as Dr. Jamie Albagetti on The CW series Emily Owens, M.D. and a starring role as Daniel Goose-Egg in the web series Soldiers of the Apocalypse, for which he also served as associate Producer. In 2013, he had supporting roles as Run in the Showcase miniseries Eve of Destruction and as the museum curator in the Hallmark Channel television movie The Hunters.