Upon West Ham's return to the Premier League, he featured in only five League games in the 2005–06 season, including those against Tottenham Hotspur on 20 November 2005 and against Manchester United on 27 November, but after a game against Blackburn Rovers on 10 December, he found regular playing time harder to come by and was sent out on loan. He did not play for West Ham at all in 2006.
Noble signed a three-month loan with Ipswich Town in August 2006 in the hope of gaining necessary first-team experience. He played 13 games in the Championship and scored his first professional goal on 12 September in a 2–1 home win over Coventry City.
Noble made his debut for the England U-21 team on 11 June 2007, coming on as substitute in the 82nd-minute for Tom Huddlestone in England's 0–0 draw with the Czech Republic during the 2007 UEFA European Under-21 Championship, held in the Netherlands. He established himself in the starting XI for the remaining matches and scored twice in a dramatic semi-final penalty shootout against the Netherlands where England lost 13–12. On 11 September 2007, Noble scored his first international goal for the under-21 team against Bulgaria in a 2–0 victory, followed by two more against the Republic of Ireland on 16 October.
Noble captained the U21s at the 2009 European Championships as regular captain Steven Taylor had to withdraw due to injury. The Young Lions ended the tournament as runners-up, losing 4–0 to Germany, with Noble playing his last match for the U21s.
During the 2011–12 season with West Ham now back in the Championship, Noble scored eight goals, seven of which were penalties, his only goal from open play coming in a 4–0 away win against Barnsley. Having twice previously been runner-up, Noble was named Hammer of the Year for the 2011–12 season. In May 2012 Noble played in the 2012 Football League Championship play-off Final at Wembley Stadium against Blackpool which West Ham won 2–1 to return to the Premier League after a one-year absence. By the end of the season, he had played 49 games in all competitions, missing just one of their Championship games.
Noble has been married to childhood sweetheart Carly since 2012. The couple have a son and a daughter.
Noble captained the England U18 team. He was a member of the England U19 team that beat Serbia and Montenegro U19s 3–1 in the 2005 European Championship semi-finals, although they subsequently lost the final to France.
Noble is also eligible to play for the Republic of Ireland national side through his Cork-born grandparents. In August 2014, despite stating on numerous occasions about his ambition of playing for England at senior level, it has been reported that he has made himself available for the Irish national team.
Noble's first goal of the season came from the penalty spot in a 3–4 home defeat by Premier League newcomers, AFC Bournemouth on 22 August 2015. The following week, he scored the second goal in a 3–0 away win against Liverpool; this was West Ham's first win at Anfield since 1963. Noble made his 350th senior appearance for West Ham on 6 February 2016, in a 1–0 defeat away at Southampton. The following week, he scored his third goal of the season, netting West Ham's equalizer in the 77th-minute of their 2–2 draw away at Norwich City. On 22 December 2015, it had been announced that Noble was to be granted a testimonial by West Ham following his long Service to the club. The game was played on 28 March 2016 between a West Ham XI and a West Ham United all-stars team made up of former players, with all proceeds going to charity. The game was won 6–5 by the West Ham XI in front of 36,000 spectators and featured a goal by Paolo Di Canio and two by Dean Ashton, including a bicycle kick described as "stunning".
In May 2016, Noble was granted freedom of the Borough of Newham for his services to the borough.
Noble marked his 300th Premier League appearance with a goal from the penalty spot against Stoke City on 16 December 2017. In March 2018, there were protests against David Sullivan and the West Ham United board at the London Stadium during a 3-0 home defeat to Burnley. There were four pitch invasions with one fan approaching Noble on the pitch. In scenes described as "horrific", Noble grappled with the supporter, throwing him to the ground.
