In the 1963-1964 season, Wyllie had a recurring role as Mrs. Kissel in 18 episodes of ABC's family western series, The Travels of Jaimie McPheeters, starring child actor Kurt Russell in the title role. Mark Allen played Matt Kissel, her husband, in nineteen episodes. In nine episodes, four of The Osmonds were cast as the singing sons of the Kissel family, all with given names of books of the Old Testament, Micah, Deuteronomy, Lamentations, and Leviticus. She played the first-ever villain in Star Trek, the Talosian "Keeper" in the pilot episode, "The Cage" (1964). Not broadcast in its original form for many years, this material was used in the two-parter, "The Menagerie" (1966).