On television, besides the role of Murdoc in MacGyver, Des Barres was also a lead cast member of The New WKRP in Cincinnati during the 1991-92 season, as part of a husband-and-wife morning team. He had previously appeared on the original WKRP in Cincinnati as the lead singer of a punk band, Scum of the Earth. During this same time, he played a gay man (Leon's boyfriend) in two episodes of Roseanne. He also played one of Darlene's baby's doctors on one of the final episodes of the series. Some of his dozens of television appearances include Seinfeld, Renegade, ALF, Ellen, Nip/Tuck, Just Shoot Me!, Hart To Hart, My Sister Sam, Lois & Clark (which reunited him with another MacGyver recurring-character alumna, Teri Hatcher - the two had even appeared together in two MacGyver episodes), JAG, Melrose Place, Nash Bridges, Northern Exposure, Rockford Files, Sledge Hammer!, Sliders, St. Elsewhere, 21 Jump Street, The Pretender, Dead Like Me, Frasier, Hawaii, Bones, and NCIS (in the Season 10 episode "Phoenix").