Manasseri was born in Poughkeepsie, New York. He is perhaps best known for his portrayal of Wyatt Donnelly in the TV series Weird Science (1994) and his voice portrayal on Santo Bugito. Manasseri also had a recurring role in the second season of the NBC sitcom Wings as young pilot Kenny McElvey. He guest starred on several TV shows, such as Buffy the Vampire Slayer, The Wonder Years, Boston Public, and ER.