Park made her entertainment debut in an SK Telecom commercial in 2005. She launched her acting career a year later in the hit sitcom Unstoppable High Kick! (2006). She continued to appear in television dramas, in roles such as the only daughter of a notorious gangster in I Am Sam (2007), and a gumiho (nine-tailed fox in Korean mythology) in an episode of horror-themed drama Hometown of Legends (2008), She played a villainous Princess in the period drama Ja Myung Go (2009), and a girl caught between two marathon runners in Running, Gu (2010).
Park's breakthrough came with the 2010 drama Sungkyunkwan Scandal, a coming-of-age drama in which her character, an intelligent and resourceful young woman, disguises herself as a boy in order to enter the most prestigious learning institution in Joseon. This was followed in 2011 by another success with City Hunter, based on the titular Japanese manga. Park starred opposite Lee Min-ho in a story about a vigilante out for revenge and justice, and the secret Service agent he falls for. Park's success on the small screen resulted in increased advertising offers for the Actress.
She starred in another manga screen adaptation in 2012; in Dr. Jin, a neurosurgeon (played by Song Seung-heon) travels back in time to 1860. Park played dual roles as the protagonist's girlfriend in the present-day (a comatose doctor), and her doppelgänger in the Joseon era (a sheltered noblewoman).
In February 2013, Park graduated from Dongguk University with a degree in Theatre.
She next played an idealistic intern in the legal drama A New Leaf (2014), who clashes with her brilliant but cynical Lawyer boss until he becomes an amnesiac (played by Kim Myung-min). This was followed by a role as a tabloid reporter in Healer, a series written by Song Ji-na that also starred Ji Chang-wook and Yoo Ji-tae. Healer was popular in China and resulted in increased recognition for Park.
In 2017, Park starred in KBS2's historical drama, Queen for Seven Days. In December 2017, Park signed with new management agency Namoo Actors.
In 2018, Park was cast in her first romantic comedy drama Why Secretary Kim alongside Park Seo-joon.
