In 1954 she appeared on stage in "In The Summer House" at the Play House in New York City. Between 1954 and 1974, Colón made guest appearances in television shows such as Peter Gunn and Alfred Hitchcock Presents. She appeared mostly in westerns such as Gunsmoke, Bonanza, The High Chaparral, and Have Gun, Will Travel. Colón appeared in the 1961 film One-eyed Jacks as "the Redhead". In 1962, she was featured as the co-star in a teleplay written by Frank Gabrielsen, and produced for the TV series The DuPont Show of the Week. The title of the hour-long episode was "The richest Man in Bogota", and it aired on 17 June 1962. It starred Lee Marvin as Juan de Núñez, and Miriam Colón as "Marina" (not Medina-Saroté, as in the original H.G. Wells story, The Country of the Blind).