Her second film, Lilya 4-Ever (2001), earned her a 2002 European Film Award nomination for Best Actress. She lost, however, to the eight actresses of the film 8 Women (2002), directed by François Ozon. For her role in Lilya 4-Ever, she also received the award for Best Actress in Leading Role from the Guldbagge Awards, Sweden's national film awards.
Since then Akinshina has acted in the films Het Zuiden, directed by Martin Koolhoven, and The Bourne Supremacy (2004), directed by Paul Greengrass.
From 2007 to 2010, Akinshina was married to businessman Dmitry Litvinov and they have a son, Philipp, born 2 June 2009. On 15 January 2013 Akinshina gave birth to her second son Konstantin, from the film Producer Archil Gelovani. On 29 January 2017 she gave birth to a daughter from Gelovani.
