Marden was born 11 June 1848 in Thornton Gore, New Hampshire to Lewis and Martha Marden. When he was three years old, his mother died at the age of twenty-two, leaving Orison and his two sisters in the care of their father, who was a farmer, hunter, and trapper. When Orison was seven years old, his father died from injuries incurred while in the woods. Consequently, the children were shuttled from one guardian to another, with Orison working for five successive families as a "hired boy" to earn his keep.