Kilbane was born in Lakewood, Ohio and attended Beloit College, where he graduated in 1990. While there, Kilbane majored in French and he began work as a stand-up Comedian. Kilbane is an alumnus of the Sigma Chi International Fraternity. After graduation, he toured the midwest for four years, spending over 40 weeks a year on the road. Kilbane would later move to Los Angeles, where he would act in commercials for Budweiser (fighting an "evil" refrigerator), The Single Guy, and HBO's Arli$$.
Kilbane joined the cast of MADtv in 1997 as a feature performer, for the third season. However, when David Herman left the show mid season, Kilbane was later promoted to a repertory performer status. Kilbane was known for many popular characters, such as the frequently appearing Stan McNer, a coffee addict with bulging eyes. Others include Nick Bendix, actor of Rocket Revengers, the Sheriff's deputy (The Son of Dolemite). He also became the second cast member to portray the Spishak salesman (David Herman was the first).
After spending 3 seasons as a cast member on MADtv, Kilbane appeared with small and supporting roles in films such as Monkeybone, Evolution, and Meet Dave. In 2003, Kilbane was considered for his own Sketch comedy show on Comedy Central called The Pat Kilbane Show. A pilot episode was filmed and produced. However, Comedy Central ending up passing on greenlighting the pilot to series.
In late 2004, Kilbane opened Wexford Hill Hobbies on Stroop Road in Kettering, Ohio. The store specialized in Gaming hobbies including role playing, table top, and miniature games. In 2007, he sold the store and it was renamed Krystal Keep by new owners. Kilbane currently resides in Woodland Hills, California.
In 2008, Kilbane reprised his Howard Stern impersonation on an episode of Frank TV.
More recently, Kilbane spent several years working with DreamWorks helping developing science fiction concepts for television. He also wrote the humorous sci-fi/horror book, "Brain Eaters Bible: Sound Advice for the Newly Reanimated Zombie", which was released on March 18, 2011. In 2012, a "Brain Eaters Bible" app for the iPad was released.
In April 2012, Kilbane moderated a web series for SOFREP.com titled "Inside The Team Room". This web series featured US NAVY SEALs Chis Osman, Brandon Webb, and Chris Kyle.
