After Italian organizations began to complain about the use of Italian Gangsters on ABC's, The Untouchables, starring Robert Stack as G-man Eliot Ness, Picerni joined the cast in 1960 as Ness's number-one aide, Lee Hobson, a role that he played for the duration of the series. (He was also seen in the program's pilot, playing Tom Lugari.) He also portrayed Ed Miller on O'Hara, U.S. Treasury (1971-1972) and was featured as Dan Garrett on The Young Marrieds (1964-66)