Whitehouse and Charlie Higson produced and appeared in a spoof phone-in show Down the Line on BBC Radio 4. The first series was broadcast May–June 2006. A second series was broadcast 16 January–20 February 2007, during which they won a Sony Radio Academy Award. A third series was broadcast in January 2008, a fourth in January 2011 and a fifth in May 2013. In February 2014, Radio 4 broadcast Nurse, written by Whitehouse and David Cummings and starring Esther Coles in the title role, with Whitehouse playing a variety of characters, including Graham Downs who had previously appeared in Down the Line.