In 1990, Aviles landed his most memorable role: Willie Lopez, killer of Patrick Swayze's Sam Wheat, in the film Ghost. The film was a smash hit at the box office and received multiple Oscar nominations. Along with Swayze, Aviles shared the screen with Demi Moore, Whoopi Goldberg and Tony Goldwyn. He also appeared in Jim Jarmusch's Mystery Train (1989) as Will Robinson; Francis Ford Coppola's The Godfather Part III (1990) as Mask #1; Brian De Palma's Carlito's Way (1993) as Quisqueya; in Waterworld (1995) as the Gatesman, and in Joe's Apartment (1996) as the voice of a cockroach.