Gullette's essays, journalism and fiction have been published in magazines including The Face, Spy, Slate, Bidoun, Brill's Content, Gear, Entertainment Weekly, Nejma, and KGB magazine (which he founded as Editor and publisher in 1991.) His essay "Mile High" appears in the NYU Press' book 110 Stories: New York Writes After September 11, and his essay "Notes" appears in the Springer-Verlag anthology Art, Technology, and Cinema.
His professional work in film began in 1998, when he co-wrote and played the lead role in the award-winning Pi, directed by longtime collaborator Darren Aronofsky. He has since played principal and supporting roles in some twenty films including Brad Anderson's Happy Accidents (with Vincent D'Onofrio and Marisa Tomei) and Darren Aronofsky's Requiem for a Dream (with Jennifer Connelly), the German film Toskana Karrussel (with Susanna Lothar) and as a guest actor on network TV dramas. His occasional theater work has included the lead in the New York premiere of Susan Sandler's If I Were a Train.
Gullette produced The 8 with Sarah Riggs and Blaire Dessent; the film was selected for the 2010 Berlin Film Festival. He directed several short films from his own scripts. He produced False Start by Yto Barrada which premiered at the Toronto Film Festival and went on to win a Tiger Award at the 2016 Rotterdam Film Festival.
In 2012, Gullette directed his first feature film, Traitors, starring Chaimae Ben Acha, Soufia Issami, Mourade Zeguindi, Driss Roukhe and Saleh Bensaleh. The film was shot on locations in Tangier, Morocco and the hashish producing Rif mountains. It made its world premiere at the 2013 Venice Film Festival , and screened in competition at the Stockholm Film Festival and at the Marrakech International Film Festival, the Dubai Film Festival, and the Tribeca Film Festival. The film was distributed internationally by Rezo Films, Paris and in the US by Film Movement. Traitors received positive reviews from critics and has a "Fresh" rating of 88% on Rotten Tomatoes, with an average score of 7.1/10.
His feature film screenwriting projects have included Trinity, Conviction, Monopolis and Kilroy. He wrote and is a Producer of Thanksgiving, starring Yolonda Ross, James Urbaniak and Seymour Cassel. He wrote "New York Stories" for Donna Karan's DKNY, and directed the "Von Hummer the 1st" series of promotional spots for VH1, starring James Urbaniak. He produced Nicole Zaray's gender-inverted short film Joe's Day, featuring Deborah Harry. He has also consulted on screenplays for Warner Bros., Paramount, and independent productions. Gullette adapted Nobel Prize–winning Japanese author Kenzaburō Ōe's novel Nip the Buds, Shoot the Kids, for an upcoming international co-production. IMDB reports Gullette as the Screenwriter of the upcoming Olivier Megaton film Land of the Living.
In 2015 he played supporting roles in the film Zanj Revolution, by Tariq Teguia and in 2013 Rock the Casbah by Laila Marrakshi.
