A life member of the Actors Studio, Van Devere played the original Meredith Lord on One Life to Live in 1968, as well as the lead in the 1972 film One Is a Lonely Number, for which she was nominated for a Golden Globe award. She appeared alongside Scott in The Last Run (1971), The Day of the Dolphin, and The Savage Is Loose (both 1973, the latter film directed by Scott), Beauty and the Beast (1976, for television), Movie Movie (1978), and The Changeling (1980).