During the 1953–1954 television season, Pearce was seen regularly on ABC's Jamie, which starred Brandon deWilde. In 1964, Pearce was originally approached to play the part of Grandmama in the ABC television comedy series The Addams Family. She turned down the part, which went to veteran Actress Blossom Rock. In 1964, Pearce joined the cast of Bewitched as the nagging and nosy neighbor Gladys Kravitz. Pearce's scenes were almost entirely reactions to the witchcraft she had witnessed at the house across the street. Her hysterical accusations against Samantha, played by Elizabeth Montgomery, and the disbelief of her husband Abner (George Tobias), provided a Common thread through many of the series' early episodes. She played the role until her death in 1966, and was replaced by Sandra Gould. Pearce was posthumously awarded an Emmy Award for this role; Davis accepted this award on her behalf.