In 1977, Wyss founded and became President of Synthes USA, the U.S. division of Switzerland-based Synthes medical device manufacturer making internal screws and plates for broken bones. In an early initiative, Wyss opened a Synthes USA Manufacturing plant in Colorado. Prior to that, another Switzerland company manufactured Synthes' devices and exported them to the U.S. Under Wyss' control, the U.S. division expanded its sales team and trained Surgeons how to use its products. Wyss served as Synthes' worldwide CEO and chairman until his resignation as CEO in 2007. He maintained his post as company chairman until Johnson & Johnson acquired Synthes in 2012. During his tenure, Wyss said discussions of new products made up one-third of board meetings. A manager assigned to the Norian project testified before a grand jury that “for somebody who is at his level and his level of success, I would say he [Wyss] has a surprising amount of contact with what's going on.” Staff recalled meetings in which he intensively probed their projects.