Klausner's first book, I Don't Care About Your Band, was released in February 2010 by Gotham/Penguin Books. In July 2010, it was announced that Will Ferrell and Adam McKay's production company, Gary Sanchez Productions, optioned the book for HBO. Lizzy Caplan was attached to star and co-produce. In 2013, Klausner published her first young adult novel entitled Art Girls Are Easy.
Klausner is head Writer and co-executive Producer of Billy on the Street, also starring Eichner. Klausner has written for television programs like Mulaney, Best Week Ever, The Big Gay Sketch Show, The Jack and Triumph Show, as well as pop culture websites like The Awl and Vulture. In 2012, Rolling Stone magazine featured her podcast How Was Your Week? in their list of "10 Best Comedy Podcasts of the Moment". In October 2011, The Hollywood Reporter reported that NBC had picked up a pilot based on Sue Margolis's novel, Apocalipstick, about a woman's father that dates her high-school nemesis; Klausner was set to write and executive produce the series. In recognition of her achievements, Klausner appears in Fast Company’s June 2012 '100 Most Creative People' issue.
Klausner was the Writer and co-star of the Hulu sitcom Difficult People, with Comedian Billy Eichner. Produced by Amy Poehler, the series debuted on August 5, 2015, and Season 2 premiered on July 12, 2016. Season 3 of Difficult People premiered on August 8, 2017. On November 14, 2017, it was announced that Hulu had canceled Difficult People. All 28 episodes will continue to be available on the streaming Service.
