Vilaysack's acting work includes a recurring role as "Nurse Kulap" on the Adult Swim series Childrens Hospital. Other television guest appearances include Bob's Burgers, The Office, The Sarah Silverman Program, The Hotwives of Orlando, Parks and Recreation, Happy Endings, Reno 911! and Whitney. In 2007, she briefly worked as an associate Producer on America's Got Talent.
With Comedian Howard Kremer, she co-hosted the podcast Who Charted? on the Earwolf network from 2010-2018.
In 2015 Vilaysack was named as one of Playboy's "32 Hottest Comediennes."
She is currently directing a documentary about her family tree entitled Origin Story with post production continuing in 2016. The film incorporates the character Katharsis of The Movement, a superhero based on Vilaysack created by author Gail Simone.
