In addition to his years of Service in various political offices in Indiana and Washington, D.C., Hendricks maintained an active law practice, which he first established in Shelbyville in 1843 and continued after his relocation to Indianapolis. Hendricks and Oscar B. Hord established a law firm in 1862, where Hendricks practiced until the Indiana General Assembly elected him to represent Indiana in the U.S. Senate in 1863. The law practice was renamed Hendricks, Hord, and Hendricks in 1866, after Abram W. Hendricks joined the firm. In 1873 it was renamed Baker, Hord, and Hendricks, after Conrad Baker, the outgoing governor of Indiana, joined the firm and Hendricks succeeded him as governor. In 1888 the firm passed to Baker's son, who partnered with Edward Daniels, and it became known as Baker & Daniels, which grew into one of the state's leading law firms.