Along with long-time friend John Lee (also of PFFR), he is the co-creator of the MTV2 series Wonder Showzen as well as the Adult Swim shows Xavier: Renegade Angel and The Heart, She Holler. The two met as undergraduates at San Francisco State University. One of his most high-profile voice acting roles is as the voice of Towelie, the marijuana-smoking talking towel on South Park, where he also serves as a staff Writer. In 2012, he became a Producer on the third season of the FX series Louie. In 2017, Adult Swim ordered The Shivering Truth, a "darkly surreal anthology comedy" from Chatman.