Fletcher directed the 2006 romantic dance film, Step Up starring Channing Tatum and Jenna Dewan Tatum. The film was nominated for two Teen Choice Awards (2007) and one Young Artist Award (2007). Although Fletcher didn't direct the sequel to this film, she choreographed on Step Up 2: The Streets (2008) which was directed by Jon M. Chu. Panned by critics, the film was well received by audiences and earned Fletcher a second successful Director credit on the popular 2008 romantic comedy film, 27 Dresses, starring Katherine Heigl and James Marsden. This film was nominated for eight awards: one People's Choice Awards (2008), two Teen Choice Awards (2008), three Golden Trailer Awards (2008), one Artios Award (2008) and one EDA Special Mention Award. Based on the success of these two initial efforts, Fletcher has gone on to direct the popular 2009 romantic comedy film, The Proposal, starring Sandra Bullock and Ryan Reynolds. This film was nominated for twenty-seven awards; out of the twenty-seven nominations, the film won seven. Following the success of The Proposal, Fletcher directed The Guilt Trip (2012) starring Seth Rogen and Barbra Streisand. She followed this by directing Hot Pursuit (2015) starring Reese Witherspoon and Sofía Vergara. This film was nominated for four Teen Choice Awards (2015).