Awards and nominations:
In 2005, Shetty was awarded the highest civilian distinction in the Emirate, the Abu Dhabi Award. Given by H. H. Sheikh Mohammed bin Zayed Al Nahyan, the Crown Prince of Abu Dhabi, the first year the distinction was awarded. Also in 2005, U.S. India Friendship Society presented Shetty the Distinguished Entrepreneur Award.
Shetty was honoured by the Pravasi Bharatiya Samman in 2007.
Ernst & Young Middle East honored Shetty with the Entrepreneur of the year finalist award in 2008.
Shetty received the Padmashree awarded by the President of India in 2009 for his contribution in the field of trade and industry.
In July 2011, he received the Asian Achievers Award from the Human Achievers Foundation.
In September 2012, Pharma Leaders founded by Satya Brahma declared Shetty as Global Indian of the Year along with Kiran Mazumdar Shaw at 5th Annual Pharmaceutical Leadership Summit & Pharma Leaders Business Leadership Awards 2012 in Mumbai.
In 2013, Shetty was recognized as one of Asia's most promising leaders at the Asian Brand & Leadership Summit. In March 2013, he was awarded the International Achievers Summit's Lifetime Achievement Award. That same year, Shetty received the Asian Business Leadership Forum India-UAE Business Icons Award. He also received the 2013 Frost & Sullivan Lifetime Achievement Award.
In 2014, Forbes Middle East recognized Shetty with the Top Indian Leaders in the UAE Award. He also received the Lakshya Business Visionary Award in 2014. That same year, Shetty was recognized with the International Achievement Award at the Indian Innovator Awards.
In February 2015, the Indian Club - Bahrain recognized Shetty with a Centenary Award. He received the Deal of the Year Award at the 2015 Indian CEO Awards. In June 2015, Shetty received the Business Personality of the Year award from Crowe Horwath International. That same month, Shetty received the Arabian Indian Czars award.
Shetty received the Global Indian Achiever Award in 2015 from H. H. Sheikh Nahyan Bin Mubarak al Nahyan. Also in 2015, H. H. Prince Faisal Bin Saud Bin Musaed Bin Abdulaziz presented Shetty with the National Cultural Award. Shetty's company, NMC Healthcare, received the Frost & Sullivan Middle East Integrated Healthcare Company of the Year Award in 2015. That same year, MILAAP honored Shetty with a Lifetime Achievement Award.
At the 2015 Gulf Business Industry Awards, Shetty was recognized as the Healthcare Business Leader of the Year. In November 2015, he was felicitated by More Ignatius Jacobite Syrian Orthodox Cathedral in Dubai. Shetty's NMC Healthcare was recognized at the 6th Middle East Business Leaders Awards in 2015, where Shetty was given the Industry Excellence in Healthcare Award.
In 2016, Shetty received the Golden Peacock Lifetime Achievement Award for Business Leadership. Also in 2016, Shetty won the Business Excellence Award from the Indian Business & Professional Council. Middlesex University in Dubai awarded Shetty an Honorary Doctorate in 2016.
In January 2017, Shetty was honored at the Annual Health Awards with a special award for his contribution to the region's healthcare industry. The following month, Shetty received the Nadaprabhu Kempegowda International Award at the Kempegowda International Festival.