In 1930, Chandler, still billed as Fehmer Chandler, joined the cast of the Liberty Bell Filling Station radio show starring Chic Sale, as Rodney Gordon, the assistant to Wheel Wilkins (Sale), proprietor of the titular gas station. Two years later, he landed a role in the Ben Hecht-Gene Fowler Broadway play The Great Magoo. Spotting him there, film Producer David O. Selznick signed Chandler, now billed under his boyhood nickname Chick, to a film contract at RKO, telling the press that Chandler was "a cross between Lee Tracy and James Cagney." Chandler, who had done behind-the-camera work for Director Charles Brabin in 1923 and had appeared in at least one silent film as an actor, turned full-time to movie acting with his first films under contract, Sweepings and Melody Cruise, in 1933. He appeared mainly in supporting roles, mostly comic, in nearly 120 films over the next 36 years.