D'Abo played Abby Carter, the ex-wife of Sheriff Jack Carter, in two 2007 episodes of the Sci-Fi Channel series Eureka. She has had numerous supporting roles in other television series and films, such as The Spirit of '76 (1990), Greedy (1994), The Big Green (1995) and The Twilight Zone (2002). On stage, she appeared in the 2005 Broadway production of The Odd Couple with Matthew Broderick and Nathan Lane.